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108 renal cancer cases were immunostained for ADAM9 on a tissue-micro-array.For 30 additional cases, ADAM9 m RNA of microdissected tumour and normal tissue was analyzed via quantitative RT-PCR.Whether the demonstrated prognostic value of ADAM9 is independent from other tumour parameters will have to be verified in larger study cohorts.A uterine tumor resembling an ovarian sex-cord tumor (UTROSCT) is a very rare lesion with only 38 cases reported in the literature so far.
Additionally, ADAM9 expression is significantly associated with markers of unfavourable prognosis.
However, in the so-called mixed UTROSCT, the endometrial stromal sarcoma component determines the outcome.
Transient receptor potential cation channel, subfamily M, member 4 (TRPM4) messenger RNA (m RNA) has been shown to be upregulated in prostate cancer (PCa) and might be a new promising tissue biomarker.
SPSS 14.0 was used to apply crosstables (Fisher's exact test and χ-test), correlations and univariate as well as multivariate survival analyses.
ADAM9 was significantly up-regulated in renal cancer in comparison to the adjacent normal tissue on m RNA level.
This type of assay ensures the specificity of the sequence of an amplified PCR product employing probes containing sequences complementary to an amplified target sequence.